Transcriptomic analysis of the innate immune signatures of a SARS-CoV-2 protein subunit vaccine ZF2001 and an mRNA vaccine RRVSARS-CoV-2 단백질 소단위 백신 ZF2001 및 mRNA 백신 RRV의 타고난 면역 특징의 전사체 분석Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] Activation Analysis Anti-viral antibody approach binding CD74 Cell comparable COVID-19 cytokine Cytokines early response elicited expression level expression of gene framework Gene Expression Genes immune response immune responses immunization innate immune innate immune response Innate immunity involved mapped MHC class mRNA mRNA vaccine neutralization Neutralization antibody Pattern recognition pattern recognition receptor Pattern recognition receptors post vaccination Protein subunit protein subunit vaccine PRRs RNA degradation robust SARS-CoV-2 SARS-CoV-2 protein subunit Subunit vaccine Tap1 titre titres Transcription transcriptional Transcriptome transcriptome sequencing Transcriptome sequencing. transcriptomic transduction Vaccine ZF2001 [DOI] 10.1080/22221751.2022.2059404 PMC 바로가기 [Article Type] Article
CASA: a comprehensive database resource for the COVID-19 Alternative Splicing AtlasArticle Published on 2022-10-202022-11-15 Journal: Journal of Translational Medicine [Category] 유전자 메커니즘, 치료기술, 치료제, [키워드] affected alteration Analysis Atla cell line conditions COVID-19 database dataset Diseases drug-target interaction event events facilitate functional annotation help host cell human cell identify immune response IMPROVE Infectious disease mechanism mechanisms Organoid performed platform profile Protein protein expression provided Quantitative data regulate Regulatory Research resource RNA RNA-seq dataset severity splicing tissues transcriptional virus [DOI] 10.1186/s12967-022-03699-8 PMC 바로가기
HLA-C dysregulation as a possible mechanism of immune evasion in SARS-CoV-2 and other RNA-virus infectionsArticle Published on 2022-10-172022-11-16 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] alteration Analysis antigenic Cell cells changes in co-morbidities COVID-19 COVID-19 patient COVID-19 patients decrease DNA DNA methylation dysregulation enhancer enhancer transcriptional regulation evade expression Gene Expression gene expression profile genes encoding healthy controls HLA-C Host immune evasion immune response immune system implicated Infection inhibit Intervention involved mechanism memory response Methylation modify overlap Pathogens presenting Prognosis Prognostic marker Protein respiratory infection SARS-CoV-2 shown significantly symptomatic and asymptomatic symptomatic and asymptomatic COVID-19 T-cell therapeutic target transcriptional upper airway upper airways cells. viral antigens virus [DOI] 10.3389/fimmu.2022.1011829 PMC 바로가기
Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19Research article Published on 2022-10-012022-10-05 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 바이오마커, 변종, 유전자 메커니즘, 임상, 진단, 치료기술, [키워드] 95% CI Activation adjusted adjusted odds ratio aggregation Alpha Analysis application B.1.1.7 Bath biochemical Biomarkers biomarkers of inflammation biopsy changes clinical factors clinical outcomes clinically Coagulation Cohort Complication correlation Council COVID-19 death develop Dexamethasone diagnostic Direct driving dysregulation of coagulation Engineering evaluated facilitate finding foundation funding hazard ratio heart hospital identify in-hospital mortality indicated Inflammation investigated mammary marker myocardial injury National Health Service NHS NIHR Non-invasive outcome Oxford parameters Pathways Patient patients with COVID-19 perivascular Platelet platform predict produced Prognostic value pulmonary angiography pulmonary CT representing respond responsible risk RNA sequencing data SARS-CoV-2 variant Science sensitivity analysis targeted therapy therapeutic target transcriptional transcriptomic Treatment Trial validation study variant vascular inflammation Wellcome Trust Whole blood wild-type SARS-CoV-2 with COVID-19 [DOI] 10.1016/S2589-7500(22)00132-7 [Article Type] Research article
Friend or foe: RIG- I like receptors and diseasesArticle Published on 2022-10-012022-11-15 Journal: Autoimmunity reviews [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] Activation anti-tumor immunity antibody Antiviral antiviral immune response Autoimmune diseases autoinflammatory disease Autoinflammatory diseases Bacterial infections cascade disease Diseases Friend genes encoding Guidance Host IFNs immunomodulatory therapy include involved malaria MDA5 mechanism mechanisms microRNA miRNAs Mutation polymorphism post-translational modification proinflammatory cytokines Proteins recent finding receptor Regulatory RIG-I RLR RLRs RLRs. RNA virus SARS-CoV-2 Signaling single-nucleotide SNPs transcriptional type I interferon [DOI] 10.1016/j.autrev.2022.103161 PMC 바로가기
SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in miceArticle Published on 2022-09-282022-11-15 Journal: Science Translational Medicine [Category] SARS, 치료제, [키워드] acute respiratory distress acute respiratory syndrome alveolar Antiviral cells chronic disease chronic inflammation clinical recovery collagen composed coronavirus coronavirus disease COVID-19 develop disease severity dysfunction dysregulated EIDD-2801 epithelial fibroblasts fibrosis histologic finding humans identify Immune cell individual Intervention lack lesion longitudinal lung abnormality lymphoid mice mouse-adapted SARS-CoV-2 murine model Nintedanib PASC Pathogenesis pathway Population proliferative provide pulmonary disease reduced regions SARS-CoV-2 SARS-COV-2 infection structures subpleural subset syndrome tissue samples transcriptional virus clearance [DOI] 10.1126/scitranslmed.abo5070 PMC 바로가기
PEDOT:PSS in Solution Form Exhibits Strong Potential in Inhibiting SARS-CoV-2 Infection of the Host Cells by Targeting Viruses and Also the Host CellsArticle Published on 2022-09-122022-11-16 Journal: Biomacromolecules [Category] SARS, 변종, [키워드] ACE2-expressing cell acute respiratory syndrome antiviral activity blocked caused Cell cells Combination coronavirus Culture cytotoxicity Effect exhibited form global pandemic high mutation rate inhibitor investigated medium Mutation Potential Prophylactic pseudovirus pseudovirus SARS-CoV-2 SARS-CoV-2 pseudovirus infection SARS-CoV-2 variant solution Spike protein Strong targeting the SARS-CoV-2 the spike protein therapeutic transcriptional transcriptomic data Transmission treated Treatment variants virus virus [DOI] 10.1021/acs.biomac.2c00271 PMC 바로가기
Single-cell RNA sequencing uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19Article Published on 2022-09-062022-11-15 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 진단, [키워드] alarmin antiviral response approach binding blood leukocyte characterized COVID-19 COVID-19 pathogenesis differentially expressed down-regulation driver expression humans Immunity immunopathology JAK-STAT pathway knockout lincRNA lncRNA long noncoding RNA LUCAT1 monocyte Monocytes naïve NF-κB NF-κB-dependent gene noncoding RNA nuclear promote promoter pseudogene PU.1 Release remained RNA RNA sequencing SARS-CoV-2 SARS-COV-2 infection severe COVID-19 Single-cell RNA sequencing single-cell RNA-seq single-cell RNA-seq. Stat1 suggested systemic immune response target Transcription transcription factor transcription factors transcriptional transgene viral infection [DOI] 10.1073/pnas.2120680119 PMC 바로가기
Hypoxia inducible factors regulate infectious SARS-CoV-2, epithelial damage and respiratory symptoms in a hamster COVID-19 modelArticle Published on 2022-09-062022-11-15 Journal: PLoS Pathogens [Category] SARS, 치료제, [키워드] Activation animal model antiviral property ciliated cells COVID-19 disease epithelial Factor FG-4592 Host hypoxia hypoxic identify increased expression Infection Infectious virus inhibit SARS-CoV-2 inhibitor intrinsic Lower respiratory tract lung epithelia microenvironment nucleocapsid expression pathological analysis pathway provide reduced reduction in regulate respiratory pathogen respiratory symptom SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 RNA significantly susceptibility therapeutic Therapies transcriptional treated understanding virus replication [DOI] 10.1371/journal.ppat.1010807 PMC 바로가기
Lipocalin-2 is an essential component of the innate immune response to Acinetobacter baumannii infectionArticle Published on 2022-09-022022-11-16 Journal: PLoS Pathogens [Category] 유전자 메커니즘, [키워드] Acinetobacter acquisition antimicrobial drug Bacteremia Bacterial bloodstream infection caused change characteristic COVID-19 pandemic Critical curtail dissemination essential nutrient evaluated exhibited expand expression expression pattern feasible gene encoding Gene Expression Gram-negative bacteremia growth Health healthcare homeostasis Host host gene expression Immunity impairment include induce Infection inhibit inhibiting innate immune response involved lack Lcn2 lipocalin-2 MDR mechanism mice Mortality multidrug resistant multifactorial organ organ-specific pathogen Pneumonia Prevalence proliferation Protective Protein required reveal robust S100A8 S100A9 secondary bacterial pneumonia sequestering survival target therapeutic tissues Transcription transcriptional Treatment upregulated ventilated patient Ventilator-associated pneumonia were infected World Health Organization [DOI] 10.1371/journal.ppat.1010809 PMC 바로가기